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Neural mechanisms of emotion in the limbic system Hisao NISHIJO 1 1Department of Physiology, Faculty of Medicine, Toyama Medical and Pharmaceutical University Keyword: 扁桃体 , 価値評価 , 離断症候群 , Klüver-Bucy症候群 pp.511-531
Published Date 1997/8/10
DOI https://doi.org/10.11477/mf.1431900968
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In the present paper, roles of various areas in the limbic system in emotion were reviewed. The limbic system has been implicated in a pivotal role in emotion since pioneering studies by Papez (1937) and MacLean (1940, 1970). Recent studies with electrical stimulation and lesions using animals, clinicopathological studies in humans, and non-invasive studies with PET and fMRI in humans indicated that the amygdala, anterior cingulate cortex, prefrontal orbital cortex, anterior temporal cortex, insula, and mediodorsal thalamic nucleus were crucial areas in emotion. These areas have mutual intimate anatomical connections and compose the basolateral limbic circuit, and work as a neural network of emotion. In this network, the amygdala receives multimodal inputs from various sensory association cortices, and is involved in evaluation of biological significance of a stimulus. In turn, the amygdala heavily projects to the hypothalamus and lower brainstem involved in emotional expression (i.e., emotional behaviors, autonomic responses, and hormonal release). Therefore, any disturbance or lesions in the sensory pathway from sensory association cortices to the brainstem including the hypothalamus through the amygdala will induce hypoemotionality or abnormal behaviors (e.g., Klüver-Bucy syndrome). This suggests that Klüver-Bucy syndrome is interpreted in terms of disconnection syndrome. Roles of other areas in the basolateral limbic circuit in emotion were discussed in reference to recent studies in humans with PET and fMRI.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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