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Role of chemokines in the lesional formation of multiple sclerosis Naoyuki TANUMA 1,2 , Yoh MATSUMOTO 2 1Department of Pediatrics, Metropolitan Fuchu Medical Center for Severe Motor and Intellectual Disabilities 2Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience Keyword: 多発性硬化症 , ケモカイン , ケモカインレセプター pp.627-635
Published Date 2006/8/10
DOI https://doi.org/10.11477/mf.1431100171
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Multiple sclerosis(MS)is an inflammatory demyelinating disease of the central nervous system(CNS). The pathological hallmark of MS consists of demyelination with inflammatory cell infiltration and axonal injury. Chemokines and their receptors are proposed to play an important role not only in the inflammatory recruitment of leukocytes into the CNS, but also in the reactive gliosis, axonal degeneration via macrophage/microglia activation, and remyelination. In this review, we have introduced recent progress in the MS research in terms of chemokines and their receptors. These studies suggest that chemokines and their receptors could be possible targets for therapeutic interventions. Some chemokine receptor antagonists are under development and phase 1-2 clinical trials for MS in the United States.


Copyright © 2006, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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