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Immunotherapy for Inflammatory Myopathies Masaya Honda 1 1Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine Keyword: 皮膚筋炎 , 多発筋炎 , 免疫介在性壊死性筋症 , 抗SRP抗体 , 抗HMGCR抗体 , dermatomyositis , polymyositis , immune-mediated necrotizing myopathy , SRP , HMGCR pp.161-169
Published Date 2021/2/1
DOI https://doi.org/10.11477/mf.1416201728
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Abstract

Inflammatory myopathies are heterogeneous disorders characterized by muscle inflammation. They are frequently accompanied by extra-muscular manifestations that affect the skin, lungs, heart, and joints. Owing to its low prevalence, wide phenotypic heterogeneity, and variable disease course, it is difficult to make clear recommendations for the treatment of inflammatory myopathies. Corticosteroids are administered as first-line treatment based on clinical experience rather than controlled trial findings. Empirically, addition of an immunosuppressive drug might offer a steroid-sparing effect or an additional benefit. Administration of intravenous immunoglobulins has been shown to be effective as second-line treatment. Recently, there has been a growing interest in assessing the potential of several biological agents in the treatment of inflammatory myopathies. There are multiple ongoing clinical trials that will lead to more treatment options for inflammatory myopathies.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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