BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 12 (December 2018)

The Basic Modules of the Neocortex Toshihiko Hosoya 1 , Nao Nakagawa 1,2 , Taisuke Yoneda 1,3 , Hisato Maruoka 1 1Laboratory for Local Neuronal Circuits, RIKEN Center for Brain Science 2Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University 3Division of Visual Information Processing, National Institute for Physiological Sciences Keyword: 大脳皮質 , 大脳新皮質 , カラム , ギャップ結合 , 細胞系譜 , cerebral cortex , neocortex , cortical columns , gap junctions , cell lineage pp.1381-1388
Published Date 2018/12/1
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The mammalian neocortex contains diverse cell types but whether they organize into repeated modular circuits remains unknown. We discovered that major cell types in neocortical layer 5 form a lattice structure in many areas of the brain. Large-scale three-dimensional imaging revealed that distinct types of excitatory and inhibitory neurons form cell type-specific radial clusters termed microcolumns. Microcolumns form a hexagonal lattice tessellating a wide region of the neocortex. Neurons within individual microcolumns exhibit synchronized in vivo activity and visual responses with similar orientation preference and ocular dominance. During early postnatal development, microcolumns are coupled by cell type-specific gap junctions and later received convergent synaptic inputs. Thus, layer 5 neurons organize into a brain-wide modular system providing a template for cortical processing.

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BRAIN and NERVE-神経研究の進歩
70巻12号 (2018年12月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院