BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 11 (November 2018)

Impairment of Cross-modality: A New Cognitive Dysfunction in Parkinson's Disease Motoyasu Honma 1 1Department of Physiology, Kyorin University School of Medicine Keyword: パーキンソン病 , 感覚間相互作用 , 視覚 , 嗅覚 , 線条体 , 眼窩前頭皮質 , Parkinson's disease , cross-modal function , vision , olfaction , striatum , orbitofrontal cortex pp.1157-1163
Published Date 2018/11/1
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It is known that Parkinson's disease impairs various cognitive functions including olfaction. However, until recently it was unclear whether Parkinson's disease also affects cross-modal function of vision and olfaction. A recent study showed that odor evaluation in patients with Parkinson's disease is unaffected by visual information, while healthy controls overestimated smell, when sniffing odorless liquid while viewing pleasant or unpleasant visual cues. Dopamine transporter deficit in the striatum, in particular in the posterior putamen, correlated with the limited visual effect in patients with Parkinson's disease. The findings suggest that Parkinson's disease impairs cross-modal function of vision and olfaction due to posterior putamen deficit. This review discusses that the cross-modal dysfunction may serve as the basis of novel precursor assessment of Parkinson's disease.

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BRAIN and NERVE-神経研究の進歩
70巻11号 (2018年11月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院