BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 67, Issue 2 (February 2015)

A Case of Neurolymphomatosis: Peripheral Neuropathy Induced by Diffuse Large B-cell Lymphoma without any Abnormal Accumulation Observed on Early Positron Emission Tomography-Computed Tomography Yuka Ebihara 1 , Nobuyuki Ishii 1 , Keiichi Akizuki 1 , Akitoshi Taniguchi 1 , Hitoshi Mochizuki 1 , Akemi Inatsu 1 , Kazutaka Shiomi 1 , Shigeki Nagamachi 2 , Masamitsu Nakazato 1 1Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki 2Department of Radiology, University of Miyazaki Keyword: 悪性リンパ腫 , positron emission tomography , neurolymphomatosis , lymphoma , positron emission tomography , neurolymphomatosis pp.219-223
Published Date 2015/2/1
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A 64-year-old woman with diffuse large B-cell Lymphoma (DLBCL) complained of double vision and pain sensation in her limbs after eight cycles of chemotherapy. F-fluorodexyglucose-positron emission tomography (FDG-PET) 7 days after the onset of double vision showed no abnormal accumulation and confirmed remission of DLBCL according to the international criteria. However, she developed limb weakness and severe paresthesia. The second FDG-PET 41 days after onset showed increased uptake at the both the brachial and lumbar plexuses, suggesting neurolymphomatosis. Although FDG-PET appears to be a highly sensitive diagnostic method for neurolymphomatosis, it is sometimes difficult to detect neurolymphomatosis in early diagnose, such as with this case. Therefore, multiple examinations are necessary to determine neurolymphomatosis.

(Received June 2, 2014; Accepted August 20, 2014; Published February 1, 2015)

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BRAIN and NERVE-神経研究の進歩
67巻2号 (2015年2月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院