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Threshold Tracking for Beginners Yoshimitsu Shimatani 1 , Hiroyuki Nodera 2 , Ryuji Kaji 1 1Department of Neurology,Tokushima University Hospital 2Beth Israel Deaconess Medical Center(Harvard Medical School,Boston,USA) Keyword: threshold electrotonus , strength-duration time constant , recovery cycle , Na channel , electrogenic Na/K pump pp.531-538
Published Date 2011/6/1
DOI https://doi.org/10.11477/mf.1416100924
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Abstract

 Nerve excitability has been studied for a longer time than has nerve conduction. Prof. Joseph Bergmans pioneered the use of threshold current measurement for studying axonal excitability. However nerve excitability testing has not been used because of technical difficulties. Prof. Hugh Bostock developed a semiautomatic program called QTRAC. This program enables the examiner to perform various nerve excitability tests within 15 min.

 Nerve excitability testing can provide information regarding physiological conditions,ion channels and the functions of energy-dependent pumps in normal controls and in individuals with diseases such as amyotrophic lateral sclerosis (ALS) and multifocal motor neuropathy (MMN). For understanding threshold tracking,information regarding basic physiological principles including the function of ion channels is required. This review provides important insights on the function of axonal ion channels and investigational methods.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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