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Brain Functional Imaging of Frontotemporal Lobar Degeneration Seigo Nakano 1 , Hiroshi Matsuda 2 1Medical Co. LTA Clinical Pharmacology Center,Honjyo Clinic 2Department of Nuclear Medicine,Saitama Medical University International Medical Center Keyword: frontotemporal lobar degeneration (FTLD) , fronto temporal dementia (FTD) , semantic dementia (SD) , progressive nonfluent aphasia (PNFA) , functional neuroimaging pp.1275-1284
Published Date 2009/11/1
DOI https://doi.org/10.11477/mf.1416100588
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Abstract

 Frontotemporal lobar degeneration (FTLD) is one of the common diseases causing dementia by including degenerative changes within the brain. The clinical subtypes of FTLD comprise frontotemporal dementia (FTD),progressive nonfluent aphasia (PNFA),and semantic dementia (SD). In this review,the role of the brain functional imaging on diagnosing of FTLD is described. Regionally distinct patterns of hypoperfusion on single-photon emission computed tomography (SPECT) or hypometabolism on positron emission tomography (PET) are helpful in differentiation of FTLD,Alzheimer's disease (AD),dementia with Lewy bodies (DLB),and corticobasal degeneration (CBD). The recently developed techniques show great promise in detecting specific neuropathological changes in dementia such as amyloid and tau pathology.


Copyright © 2009, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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