Capsaicin Receptor TRPV1 Makoto Tominaga 1 1Section of Cell Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences Keyword: nociception , TRPV1 , TRP channels , TRPA1 pp.493-501
Published Date 2008/5/1
DOI https://doi.org/10.11477/mf.1416100273
  • Abstract
  • Look Inside
  • Reference


 Transient receptor potential vanilloid 1 (TRPV1) is a receptor for capsaicin, which is a main ingredient in hot chili peppers, and belongs to the TRP ion channel superfamily. Researchers have confirmed that TRPV1 is activated by multiple nociceptive stimuli including protons, noxious heat and some lipids both in the heterologous expression system using the cloned channels and native sensory neurons. In addition, studies using mice lacking TRPV1 revealed its importance at the behavioral level. Since 1997, when TRPV1 was first cloned, a considerable amount of information has accumulated regarding its agonists, the mechanisms involved in its activation and regulation, and the structural bases of these mechanisms. Furthermore, several clinical trials involving the use of TRPV1 antagonists as analgesic agents are currently underway. With success, some of these agents may enter the market in the near future.

Copyright © 2008, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院