排尿障害に対して抗コリン薬が有効であった多発性硬化症

EFFECTIVENESS OF ANTICHOLINERGIC DRUGS ON UNINHIBITED CONTRACTION OF URINARY BLADDER COMPLICATED WITH MULTIPLE SCLEROSIS

　ステロイド大量療法が無効であった多発性硬化症の膀胱無抑制収縮による頻尿，切迫性尿失禁を示した2症例に対しオキシブチニン，テロジリンを投与したところ，無抑制収縮の消失ならびに切迫性尿失禁の消失，頻尿の改善を認めた．多発性硬化症に原因する無抑制収縮の治療に際し，一般的な治療法で排尿症状の改善が無効の場合はこれら膀胱に特異的な治療法を試みるべきである．

Oxybutynin and Terodiline were administrated to two patients with multiple sclerosis refractory to high dose steroid therapy, who had pollakisuria and urge incontinence owing to uninhibited contraction of urinary bladder. The results were the disappearance of the urge incontinence and improved pollakisuria. We feel that specific treatment using these agents should be attempt for uninhibited contraction of urinary bladder caused by multiple sclerosis if general treatments failed to improve urinary symptoms.