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初発の膀胱移行上皮癌患者のうち表在性(stage pTa,pT1)で,低異形度(grade l,2)の症例46例に対し再発予防を目的として経尿道的切除術(TUR)直後に高線量照射を施行した.方法は,手術直後に膀胱部に5Gy,その後週2回,総線量20 Gy(計4回)の体外照射治療(linac)を行った.結果は実測再発率が1年4.7%,2年7.5%,5年7.5%であった.また,放射線治療による重篤な副作用はなかった.この結果は,TUR後無治療の場合や従来の放射線治療と比べて良かっただけでなく,TUR後膀胱内に抗癌剤やBCGの注入を行った場合と比較しても優れていた.
Radiotherapy immediately after transurethral resection (TUR) was performed in 46 patients withsuperficial (stage pTa and pT1) and low grade (grade 1 and 2) bladder cancers as a prophylaxis againsttumor recurrence. All patients received TUR and external irradiation (linac,5Gray twice a week, total doseof 20 Gray) for whole bladder field were started immediately after TUR.The mean observasion period was38.5months and the actual probability of the recurrence rate of bladder cancers was 4.7%in one year,7.5%in two years and 7.5% in five years.
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