A patient with bladder cancer who responded to GC(gemcitabin, cisplatin)therapy, but died of meningeal carcinomatosis:a case report Tohru Furuuchi 1 , Ken Marumo 1 , Hiromichi Ishikawa 1 , Yasumasa Hanawa 2 , Jun Hagiuda 1 , Masahiro Katsui 1 1Department of Urology, Ichikawa General Hospital, Tokyo Dental College 2Department of Urology, Minami Tama Hospital Keyword: 膀胱癌 , 転移性髄膜腫瘍 pp.167-170
Published Date 2013/2/20
DOI https://doi.org/10.11477/mf.1413103026
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A 79-year-old man with invasive bladder cancer and metastases to the iliac and para-aortic lymph nodes underwent three courses of preoperative GC(gemcitabin, cisplatin)therapy, followed by total cystectomy and ileal conduit diversion. Histopathologic examination of the resected specimen revealed urothelial carcinoma, G3, pT2b, ly0, v0, with lymph node metastasis. CT performed three months later revealed no lymph node metastasis. However, CT conducted six months postoperatively showed multiple lymph node metastases, and GC therapy was resumed. Although a repeat CT after completion of two courses of GC therapy revealed shrinkage of the lymph node metastases, the patient began to show disorientation and lower-extremity weakness during the second course of GC therapy and head MRI and cerebrospinal fluid examination revealed the diagnosis of meningeal carcinomatosis. The patient was then administered palliative care instead of aggressive treatment, but died approximately one month after the diagnosis of meningeal carcinomatosis.

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