Acanthosis nigricans congenitalisの2例

TWO CASES OF ACANTHOSIS NIGRICANS CONGENITALIS

I．はじめに

　Acanthosis nigricansは1890年，Pollitzer及びJanovskyが夫々独立に記載したのに始まる比較的稀れな疾患で，（1）好発部位にみられる乳頭様増殖，（2）色素増生，（3）臨床的に著しくなくても組織学的には必ず証明できる角質増殖を3主徴とする^1）。

　本症は悪性腫瘍との合併率が高いゆえに，皮膚科医のみならず他科の医師によつても注目される疾患の1つであるが，中に悪性腫瘍を合併しない良性の経過をとるもののある事が古くから注目されており，その原因，分類に就てはDarier以来屡々論議されてきた。

Two cases of acanthosis nigricans congenitalis were reported.

Case 1 : A 9-year-old girl showed verrucous dark-brown lesions with lichenification on the neck, umbilical region, in the genital and axillary region and on the buttock at birth.The scalp hair was dark and thick. The vellus hair of the upper extremities was rather long and dark. The teeth were large and arranged irregularly. The mucous membrane of the mouth, cheek and tongue were granular and verrucous with deep fold formation. Roentgenogram of sella turcica was slightly small. Slight retardation of adrenal response to ACTH was proved by Thorn test.

Case 2 : A boy of one year and 4 months of age with livercirrhosis had dark-brown and velvety lesions with lichenification on the neck, extensor aspects of the wrists and feet, in the axillae and the interdigital spaces of the feet.

His past history failed to verify the time of onset of the lesion

Histologic specimens from the neck of the two cases showed typical picture.