血清抗体測定によるChlamydia PsittaciおよびChlamydia trachomatisと耳鼻咽喉科疾患との関連性に関する検討

Seroepidemiology of Chlamydia psittaci and Chlamydia trachomatis Infection in Patients with Otorhinolaryngeal Diseases

　はじめに

　クラミジアは微生物学上の分類ではⅡ　門（Bac-teria）第18部（Rickettiales目，Chlamydiales目）に属し，1科1属で，現在はChlamydia psittaci，Chlamydia trachomatis，Chlamydia pneumoniaeの3種からなる。

　C．Psittaciはおうむ病（psittacosis）の病原体でC．trachomatisはトラコーマ，鼠径リンパ肉芽腫，近年では非淋菌性尿道炎などの性感染症や乳児の無熱性肺炎を起こすことが明らかになった菌である。筆者らはC．pneumoniaeと耳鼻咽喉科疾患との関連性については，血清学的に調べても非常に高いものがあることを認め本誌上で報告した^1）。また，滲出性中耳炎や種々の扁桃炎患者からC．tra-chomatisを分離培養し，これらの耳鼻咽喉科疾患における病原性について論じてきた^2〜4）。

Antibodies to C. psittaci and to C. trachomatis were measured by the microimmunofluoreseenee method to evaluate the relationship between the agents and otorhinolaryngeal diseases. No patients had antibody titer higher than 64 to C. psittaci, and they had no 1gM antibody to the organism either. However, some patients had a high titer of antibody to C. trachomatis. Eight of 56 (14%) patients with tonsillitis, 8 of 38 (21%) with otitis media, 5 of 68 (7%) with bronchitis, 3 of 45 (7%) with common cold syndrome but none with sinusitis had antibodies indicating current or recent infection with C. trachomatis. The data suggest that C. psittaci dose not play an active role, but C. trachomatis appears to play an impor-tant role in upper respiratory tract diseases including otitis media.