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Current clinical and research approach in keratoconjunctival disorders Mitsuru Sawa 1 1Department of Ophthalmology, Nihon University School of Medicine pp.229-240
Published Date 2002/3/15
DOI https://doi.org/10.11477/mf.1410907620
  • Abstract
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Principal clinical examination method for kerato conjunctival diseases is slit-lamp microscopy. However, slit-lamp microscopy is primarily qualitative and subjective method and involves liminations in evaluation of pathological findings and diagnosis. Therefore, other supportive methods to understand pathologi-cal findings or diagnostic methods are indispensable for better understanding in ocular surface disorders. The paper reports currently available clinical diagnostic or examination methods including a novel method to deter-mine an area of corneal surface defect and the following issues.

1) Allergic disorders ; significance of methods to determine antigen specific IgE antigen and eosinophil cati- onic protein in tear fluid, and animal model for local immune system and study on mucosal immunological treatment.

2) Infectious disorders; clinical use of polymerase chain reaction or antigen detection method for herpetic keratitis or C. trachomatis infection. Study on pathopysiology in immune ring and corneal ulcer.

3) Chemical burn; treatment of chemical burn for ocular surface and study on efficacy of conjunctiva auto- graft in animal model. Culture study of conjunctival epithelium on amniotic membrane.

4) Corneal dystrophy; genetic analysis and its clinical application.


Copyright © 2002, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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