筋注用ペントバルビタール・ナトリウム麻酔剤による動物実験成績

The animal experiments of Pentobarbital natrium for intramuscular injection.

　先に米村と私は，筋注用ペントバルビタール・ナトリウム（田辺製藥試作剤）を眼科領域の各種手術に於て前投藥として使用した経験に就て報告したが，此の度，私は，之を動物実験に供し麻酔効果のみならず諸臓器に与える影響を病理組織学的に検索したのでその結果を茲に報告する。

The experiments of Pentobarbital natrium for intramuscular injection (0.15 G. /cc. produced by Tanabe Pharmacy Co.) were done in the rabbits and the following results were obtained.

1) By the administration of 30 mg. per kg., the unconciousness was obtained. The minimum fatal dose was 70mg. per kg.

2) The main pathological signs of the rabbts to which the fatal dose were given were the sta-gnation of kideny, hyperemia of glomerulus and atelectasis.

3) The main patorlogical signs of the rabbits which were striked to death after the two times injection of 30mg. per kg. for two days. and in which the 4 times injection of 40 mg. per kg.