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脊椎圧迫骨折は腫瘍性椎体骨折か骨粗鬆症性椎体骨折かの鑑別が困難なことがある.転移性骨腫瘍は骨組織を破壊しながら拡大していくために,骨吸収マーカーが上昇する.新規椎体骨折で来院した患者45例(平均年齢70.4歳)について治療開始前に尿中NTxを検査した.腫瘍性椎体骨折症例において有意にNTx(腫瘍群109.2,骨粗鬆症群70.2)は高値を示した(p=0.0337).また転移巣が増加するほどNTxは増加する傾向にあった(p=0.0586).NTxが高値を示した際には腫瘍性椎体骨折を疑って精査を行う必要がある.
Diagnosing pathological spinal fractures may require further examination, e.g., by MRI and bone scintigraphy. Bone absorption was evaluated by U-NTx in 45 patients (average age 70.4 yo)with fresh vertebral fractures. U-NTx was significantly higher in those with pathological vertebral fractures than in those with osteoporotic fractures (tumor:109.2, osteoporosis:70.2, p=0.0337). U-NTx correlated slightly with the total number of metastatic lesions (p=0.0586). U-NTx presents bone absorption, however, so U-NTx is also influenced by metabolic bone changes, e.g., steroid intake, ovariectomy, gastrectomy, etc. U-NTx is useful and noninvasive, and we found it helpful in evaluating pathological changes in bone.
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