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Japanese

THE STUDY OF INTRATUMORAL PO2 IN BRAIN TUMORS Takamasa Kayama 1 , Akira Ogawa 1 , Yoshiharu Sakurai 1 , Tokuo Wada 1 , Mamoru Murakami 2 , Takashi Yoshimoto 3 , Jiro Sukuki 3 1Department of Neurosurgery,Sendai National Hospitol 2Department of Anesthesiology,Sendai National Hospitol 3Division of Neurosurgery,Institute of Brain Diseases, Tohoku University School of Medicine pp.319-325
Published Date 1988/4/1
DOI https://doi.org/10.11477/mf.1406206083
  • Abstract
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The aim of this study was to evaluate the hypoxic cells in the human brain tumor in vivo. Untreated 16 cases of brain tumor were analysed. During the surgery for the purpose of removal of the tumor, needle type-O2 sensors were insert-ed into femoral artery and in brain tumor to measure PaO2 and intratumoral O2 pressure. A plate type O2 sensor was put on the surface of surrounding brain cortex to measure cortical O2 pressure. These O2 sensors for this study is able to measure O2 pressure continuously and to ob-serve these three O2 pressure simultaneously. Operations were performed endtracheal anesthesiaunder inhalation of ethrane with maintaining sys-tolic blood pressure 120 mmHg. Setting the rate of O2 and N2O gas inhalation 1/3, PaO2 revealed about 110 mmHg which is similar value as phy-siological state-1 ATM, air inhalation-. The value of TuO2 and BrO2 were revealed 15.3±2.3 (mean±SE) mmHg and 59.8±6.5 (mean±SE) mmHg. According to these results, it might be said that hypoxic fraction surely exist intra-tumoral tissue. It is also well known that O2 re-moves from higher pressure zone to lower pres-sure zone after O2 was diffused from red blood cell in brain tissue. It might be also mentioned that much lower hypoxic fraction than the value of this study is exististing intratumoral tissue.

It has long been recognized that hypoxia influ-ences the response of cells and tissues to radia-tion. However, they have been suspected on the basis of experimental data in vitro. This study showed hypoxic fraction in human brain tumor tissue in vivo.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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