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REGIONAL CEREBRAL BLOOD FLOW IN CHILDREN-NORMAL VALUE AND REGIONAL DISTRIBUTION OF CEREBRAL BLOOD FLOW IN CHILDHOOD Akira Ogawa 1 , Nobuyuki Nakamura 1 , Kyouichi Sugita 1 , Yoshiharu Sakurai 1 , Takamasa Kayama 1 , Tokuo Wada 1 , Jiro Suzuki 2 1Department of Neurosurgery, Stroke Center, Sendai National Hospital 2Division of Neurosurgery, Institute of Brain Diseases, Tohoku University School of Medicine pp.113-118
Published Date 1987/2/1
DOI https://doi.org/10.11477/mf.1406205848
  • Abstract
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The changes in CBF and rCBF through the entire age range include the rapid period in childhood was reported.

Sixteen children between the ages of 1 and 15 add 14 adults were studyed. These 30 subjects were either volunteers of out-pationts without CT and EEG abnormalities. rCBF was measured by the 133Xe intravenous injection method using Var-met rCBF analyzer. Ther relationship between age and CBF, the correlation coefficient was cal-culated based on the regression equations and the regression curve with the highest correlation was chosen. For the analysis of rCBF, he mean rCBF values (ISI) of 3 channels corresponding to the frontal, temporal, parietal and occipital lobes were expressed as a percentage of the hemispheric CBF.

The hemispheric blood flow (ISI and CBF gray) of children less than 5 years of age was approxi-mately twice that found in adults. This value decreased rapidly with age and in the 10-15 years the blood flow was approximately 1.3-fold that of adults. Thereafter, there was a slow decrease and a negative correlation with age was found. The decrease showed the correlation on the fol-lowing equations ; y=146.5-58.5log x. (r=-0.903) for ISI and log y=2.26-0.29 log x. (r=- 0.881) for CBF gray, which was statistically sig-nificant. In contrast, the CBF white showed a slightly higher value in the 1-2 years old child-ren, but thereafter the CBF did not show a notable decreases with age. Through the entire age range, a best fit for the Fw values was found with : y= 18.3+37.5/x. (r=0.798), which was also statisti-cally significant.

The regional flow distribution in the children under 5 years of age were 96.2±2.1, 101.9±1.9, 101.1±1.6 and 104.6±3.1%, respectively, at thefrontal, parietal, temporal and occipital regions. That is, a relatively high value was found poste-riorly and a relatively low value anteriorly. In the children between 5 and 9 years of age, the distribution was, respectively, 102.1±2.1, 100.0 ±1.7, 99.6±3.2 and 98.8±3.2% showing a re-versal of the earlier pattern, such that now rela-tively greater blood flow was found anteriorly. In the children between 10 and 15 years of age, the rCBF pattern was 105.1±2.2, 101.8±2.6,97.7±1.5 and 99.9±2.8%, respectively. Here the highest value was at frontal cortex. The pattern in adults was similar to that of the 10-15 years old group (105.0±4.4, 101.9±4.7, 96.2±4.1 and 100.6±4.2, respectively). Significant differences were found between group 1 and group 2 and be-tween group 2 and group 3, but a difference be-tween group 3 and the adult group was not found.


Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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