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Japanese

PROTECTIVE EFFECT OF THROMBOXANE A2 SYNTHETASE INHIBITOR (TRAPIDIL) ON ACUTELY-INDUCED CEREBRAL ISCHEMIA Yasuo Katayama 1 , Jun Shimizu 1 , Hajime Memezawa 1 , Hiroaki Minamisawa 1 , Satoru Suzuki 1 , Sigeru Sugimoto 1 , Akiro Terashi 1 1Second Department of Internal Medicine, Nippon Medical School pp.925-931
Published Date 1986/10/1
DOI https://doi.org/10.11477/mf.1406205783
  • Abstract
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The experimental study presented was under-taken to evaluate the role of thromboxane A2 contributing to aggravating cerebral ischemia, and to examine the effect of a thromboxane A2 synthe-tase inhibitor, trapidil on cerebral ischemia. Cerebral ischemic model was induced in 16 week old spontaneously hypertensive rats (SHR) by bilateral common carotid artery ligation (BLCL). Two doses of trapidil 15 mg/kg was intraperito-neally administered one dose 2 hr before and one dose 15 min after BLCL in SHR. While control animals only underwent BLCL. Brain tissue meta-bolites such as ATP, lactate and pyruvate, brainwater content and plasma thromboxane B2 and 6 Keto PGF. were determined 3 hr after BLCL. Scanning electron microscopic observations were also recorded.

ATP concentrations were 1. 36±0.23 n moles/mg wet tissue in the trapidil treated group, 0. 61±0.26 n moles/mg wet tissue in the control group, the difference between the treated and the control being significant (P<0. 001). Lactate concentrations were 4. 70±1. 20 n moles/mg wet tissue in the treated group, 12. 17±8. 53 n moles/mg wet tissue in the control group, the difference between the treated and the control being significant (P<0.02). Pyruvate concentrations were 0. 59±0.11 11 n moles/ mg wet tissue in the treated group, 0. 43±0. 16 n moles/mg wet tissue in the control, the difference was also significant (P<O. 05).

Average water content was 78. 87-±0. 59% in the treated group, 79.82±0. 33% in the control. There was a statistical difference between the two groups (P <0.01).

The treated group had a tendency of decrease of plasma thromboxane B2 and a tendency of increase of plasma 6 Keto PGF., and had a stati-stical difference of thromboxane B2/ 6 Keto PGF ratio from those of the control group (P <0. 05). In scanning electron microscopic observation, the treated rats had very few adhering fibrin nets and blood born cells in the surface of the endothelial cells in the intracerebral arterioles and the middle cerebral artery, whereas the control rats showed remarkable vasoconstriction and had many micro-villi, many adhering fibrin nets and blood born cells.

The present results show that a thromboxane A2 synthetase inhibitor, trapidil ameliorates im-paired cerebral metabolism and brain edema in acutely-induced cerebral ischemia. It indicates that an increased thromboxane A2 and thromboxane A2 priority to PGI2 in cerebral ischemia play an important role as an aggravating factor of ische-mia through the disturbance of microcirculation.


Copyright © 1986, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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