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Japanese

Efficacy and Safety of Duloxetine in Outpatients with Major Depressive Disorder in Clinical Practice Taketoshi MATSUKI 1 , Sachiko TANAKA 1 1Matsuki Clinic, Shimonoseki, Japan Keyword: SNRI , SSRI , Duloxetine , Major depressive disorder , MDD pp.303-308
Published Date 2014/4/15
DOI https://doi.org/10.11477/mf.1405102694
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 The efficacy and safety of duloxetine was investigated in 57 outpatients diagnosed with a major depressive disorder lasting more than 4 weeks in a psychiatric clinic. Of the 57 patients, 23 were newly diagnosed and 34 had switched from SSRI treatments. Efficacy of duloxetine was evaluated using the Self-rating Depression Scale (SDS) and Clinical Global Impression of Change (CGI-C) by comparing the scores before and after treatment.

 SDS score was significantly improved from 55.2±8.1 to 50.5±9.9 (p<0.001) in all patients. Symptomatic improvement was observed in 66.0% of patients on the CGI-C. Effectiveness was also observed when confined only to the patients who switched from SSRIs. Six patients (10.5%) did not complete the study because of adverse effects;the proportion of dropouts from duloxetine treatment was slightly lower than previously reported.

 Duloxetine is a highly effective, well-tolerated, and useful drug in the treatment of major depressive disorder.


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電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

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