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Smoking and Magnesium Deficiency:Possible risk factors for vasospastic angina Naohito Tanabe 1 , Kenichi Watanabe 2 , Yoriko Kusano 2 , Seiichi Miyajima 2 , Takashi Washizuka 3 , Katsuyuki Sakai 3 , Masami Shiba 3 , Yukie Ochiai 3 , Tadashi Satoh 3 , Nao Seki 1 , Senji Hayashi 1 , Akira Shibata 3 , Hiroshi Suzuki 1 1Department of Public Health, Niigata University School of Medicine 2Division of Cardiology, Tsubame Rosai Hospital 3The First Department of Internal Medicine, Niigata University School of Medicine Keyword: 冠攣縮性狭心症 , マグネシウム , 喫煙 , vasospastic angina , magnesium , smoking pp.1293-1297
Published Date 1996/12/15
DOI https://doi.org/10.11477/mf.1404901387
  • Abstract
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To determine the role of usual coronary risk factors and magnesium deficiency in vasospastic angina, 18 patients with vasospastic angina without fixed stenosis of coronary arteries (VSA group) were compared with 13 controls with neither fixed coronary stenosis nor ergonovine-induced coronary artery spasm (non-VSA group). Magnesium deficiency was diagnosed when the 24-hour magnesium retension amount was 50% or higher in the magnesium loading test.

In univariate analysis, subjects with magnesium deficiency (38.9% vs. 7.7%), low level of serum high-density lipoprotein (HDL) cholesterolemics (50.0% vs. 15.4%) and current smokers (55.6% vs. 23.1%) tended to be more frequent in the VSA group than in the non -VSA group (p<0.10), whereas other usual coronary risk factors were not different between the groups (p≧0.10). To calculate adjusted odds ratios and the confidence intervals for VSA by smoking, and low HDL cholesterol and magnesium deficiency, we applied a multivariate logistic regression analysis, in which all three factors and age were adjusted. The adjusted odds ratio and 95% confidence interval among smokers was 34.56 and 1.75-679.54, respectively. The adjusted odds ratio and 90% confidence interval in cases where there was magnesium deficiency was 13.73 and 1.25~150.70, respectively. The adjusted odds ratio for low HDLC was statistically insignificant (p≧0.10).

From these results, smoking and magnesium deficiency appeared to be possible risk factors for vasospastic angina.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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