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Elevated Plasma Interleukin-1 Receptor Antagonist and Interleukin-10 in Patients with Acute Myocardial Infarction Masashi Shibata 1 , Shigeatsu Endo 1 , Norio Sato 1 , Naoshi Arakawa 1 , Tomomi Suzuki 1 , Hidehiko Aoki 1 , Tomoyuki Suzuki 1 , Satoshi Kuriki 2 , Masako Harada 2 , Ikuo Segawa 2 , Katsuhiko Hiramori 2 , Katsuya Inada 3 1Critical Care and Emergency Center, Iwate Medical University 22nd Department of Internal Medicine, Iwate Medical University 3Department of Bacteriology, Iwate Medical University Keyword: インターロイキン−1受容体拮抗物質 , インターロイキン−10 , 急性心筋梗塞症 , interleukin-1 recepter antagonist , interleukin-10 , acute myocardial infarction pp.635-640
Published Date 1996/6/15
DOI https://doi.org/10.11477/mf.1404901273
  • Abstract
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The main pathogenetic factor causing shock and organ dysfunction in critically ill patients is the variety of host responses to severe clinical insults. Cytokines are known to play a central role in these pathogenic mechanisms. In the present study, we attempted to define the kinetics of plasma interleukin-1 receptor antagonist (IL-1ra) and plasma interleukin-10 (IL-10) in patients with acute myocardial infarction (AMI) (n=27, age 42.91yr, mean 66yr). Plasma IL-1ra levels and plasma IL-10 levels were measured by enzyme-linked immunosorbent assay. Patients in Group 1 (n= 17) had severe AMI (Killip class 2, 3 or 4). Patients in Group 2 (n=10) had uncomplicated AMI (Killip class 1). Peak IL-lra levels and peak IL-10 levels in Group I were significantly higher (p<0.05) than those of Group 2. In Group 1, the peak IL-1ra levels were significantly correlated with white blood cell counts (r=0.63, p=0.006), pulmonary wedge pressure (r=0.78, p= 0.0002) and cardiac index (r=-0.51, p=0.04). Peak IL-10 levels were significantly correlated with white blood cell counts (r=0.60, p=0.01), the pulmonary wedge pressure (r =0.73, p =0.0008) and cardiac index (r=-0.50, p=0.04). Moreover, a significant correlation was found between the peak IL-1ra levels and peak IL-10 levels (r=0.91, p<0.0001). The peak IL-1ra levels in non-survivors (n=6) were significantly higher (p< 0.01) than those in survivors (n=21).

The plasma IL-1ra levels and plasma IL-10 levels were closely correlated with the severity of hemodynamics in AMI and with the clinical status of patients with severe AMI. Results suggest that IL-1ra and IL-10 can serve as prognostic indicators in cases of severe AMI.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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