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A Suspicious Case of Drug Induced Lung Injury Caused by Daikenchuto(TU-100) Shintaro Suzuki 1,2 , Yasunari Kishino 2 , Hironori Sagara 2 1Krefting Research Centre, University of Gothenburg, Gothenburg, Sweden 2Department of Medicine, Section of Respiratory Medicine and Allergology, School of Medicine, Showa University Keyword: 大建中湯 , 薬剤性肺障害 , 漢方薬 , Daikenchuto , drug induced lung injury , Medicine , Kampo pp.313-318
Published Date 2016/3/15
DOI https://doi.org/10.11477/mf.1404205928
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 Background:Daikenchuto has frequently been used for several disorders of digestive system.

 Case report:76 years old male had hepatocellular carcinoma and been admitted to our hospital in purpose of an operation of hemihepatectomy. He started to take daikenchuto seven days before the operation. He complained dyspnea on exercise and dry cough on 4th day post operation. Chest X ray and CT showed diffuse ground grass opacity mainly in lower fields of bilateral lungs. In this stage bacterial pneumonia was suspected, but antibiotics did not effectively improve his condition. The lung opacity gradually got worse. We were consulted to see him and suspected it would be drug-induced lung disorder(DILD)caused by Daikenchuto. After cessation of taking Daikenchuto, his symptoms and lung opacity immediately improved. Later, lymphocyte stimulation test with Daikenchuto was proven to be positive, therefore we diagnosed him as having DILD caused by the medicine.

 Discussion:Although Daikenchuto is the best selling remedy in a field of wakan medicine, there has been a few reports of lung disorder caused by it. When a patient complains any respiratory symptom and diffuse ground grass opacity is observed in chest X-ray or CT after taking Daikenchuto, we should consider it as a cause of drug-induced lung disorder.


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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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