雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

A Female Patient with Antithrombin Deficiency whose Deep Vein Thrombosis was Well Dissolved using Catheter Directed Thrombolysis Hiroyuki Kawahito 1 , Yoshifumi Nakahara 1 , Atsushi Hoshino 1 , Satoko Enomoto 1 , Hiroyuki Kurata 1 , Takashi Nakamura 1 , Isao Kitajima 2 , Hideki Niimi 2 1Department of Cardiology, Saiseikai Shiga Hospital 2Clinical Laboratory, Toyama University Hospital Keyword: 深部静脈血栓症 , 先天性アンチトロンビン欠損症 , catheter-directed thrombolysis , deep vein thrombosis , antithrombin deficiency , catheter directed thrombolysis therapy pp.219-223
Published Date 2008/2/15
DOI https://doi.org/10.11477/mf.1404100987
  • Abstract
  • Look Inside
  • Reference

 A 27-year-old pregnant woman(9 weeks 2 days) consulted our hospital due to right leg swelling and numbness. We found widespread DVT from the iliac to the popliteal vein on ultrasonography. We started anti-coagulation therapy using, heparin after implantation of an IVC filter at the upper part of the renal vein to prevent pulmonary embolism and allow continuation of pregnancy. We initially found decreased AT antigen level and activity and replenished her antithrombin. However thrombosis worsened and she became unable to bend her leg due to pain and edema.

 Because of our concern about the progression of venous necrosis due to her acute perfusion disorder, we inserted an infusion catheter from the popliteal vein and continuously injected urokinase with intermittent pneumatic compression after abortion. Two days later, thrombus in the iliac vein along with leg edema had almost disappeared. Thrombolysis is available for deep vein thrombosis, but we often experience difficulty in dissolving thrombus by systemic infusion or peripheral venous infusion. In this case, catheter directed thrombolysis was very effective for quickly improving symptoms and leg edema. Antithrombin antigen levels of the patient's mother, brother and daughter were also decreased by about 50%. Thus we later diagnosised both siblings as having congenital antithrombin deficiency.


Copyright © 2008, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

関連文献

もっと見る

文献を共有