Gastric Cancer with Hyperplastic Foveolar Epithelium, Report of a Case Tetsuji Kudo 1 , Katsuya Hirakawa 1 , Masahiro Kondo 1,2 , Satoshi Utsumi 1 , Takamasa Yoshihara 1 , Akihito Yokote 1 , Akiko Nomura 1 , Daisuke Akiyoshi 1 , Daichi Kitahara 3 , Kenichi Nishiyama 3 , Hidechika Horie 4 , Kunihiko Aoyagi 1 , Takehiro Torisu 2 1Department of Gastroenterology, Japanese Red cross Fukuoka Hospital, Fukuoka, Japan 2Departments of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 3Department of Pathology, Japanese Red cross Fukuoka Hospital, Fukuoka, Japan 4Department of Surgery, Oguni Municipal Hospital, Kumamoto, Japan Keyword: 胃過形成性ポリープ , 癌化 , 胃癌 , H. pylori , 除菌 pp.880-886
Published Date 2021/5/25
DOI https://doi.org/10.11477/mf.1403202477
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 A 60s woman was diagnosed with pedunculated hyperplastic polyps in the greater curvature of the gastric body 10 years earlier. She had been undergoing a follow-up study by EGD. Three years after H. pylori eradication therapy, an endoscopic examination showed morphological changes in the polyp. The biopsy specimen demonstrated a well-differentiated adenocarcinoma, and the patient was referred to our hospital. Histopathological examination after ESD revealed a well-to-poorly differentiated adenocarcinoma with hyperplastic foveolar epithelium. Additional surgery was performed because severe lymphatic and submucosal invasion were observed. A retrospective review of the endoscopic findings showed that the hyperplastic polyps had shrunk and the cancerous area had increased after the eradication therapy. Hyperplastic polyps require careful observation considering their malignant transformation even after successful eradication of H. pylori.

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