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要旨●患者は60歳代,女性.10年前から胃体下部大彎にポリープを指摘され,過形成性ポリープの診断で経過観察中であった.3年前にH. pylori除菌治療が行われたのち,ポリープの肛門側に不整な陥凹を伴う平坦隆起が出現し,生検にて高分化腺癌と診断され当科受診となった.ESDを施行し,過形成性ポリープの組織構築に類似する超高分化腺癌とそれに連続する中〜低分化腺癌を肛門側に認めた.いずれも免疫組織化学染色でMUC5AC陽性であり,過形成性ポリープの癌化が示唆された.粘膜下層浸潤とリンパ管侵襲を伴っていたため追加手術を行ったが,局所遺残やリンパ節転移は認めなかった.内視鏡所見を遡及的に検討すると,直近の1年間で過形成性ポリープが縮小し,癌の領域が増大していた.
A 60s woman was diagnosed with pedunculated hyperplastic polyps in the greater curvature of the gastric body 10 years earlier. She had been undergoing a follow-up study by EGD. Three years after H. pylori eradication therapy, an endoscopic examination showed morphological changes in the polyp. The biopsy specimen demonstrated a well-differentiated adenocarcinoma, and the patient was referred to our hospital. Histopathological examination after ESD revealed a well-to-poorly differentiated adenocarcinoma with hyperplastic foveolar epithelium. Additional surgery was performed because severe lymphatic and submucosal invasion were observed. A retrospective review of the endoscopic findings showed that the hyperplastic polyps had shrunk and the cancerous area had increased after the eradication therapy. Hyperplastic polyps require careful observation considering their malignant transformation even after successful eradication of H. pylori.
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