The Relation between the Histological Types of Gastric Carcinoma and the Mode of Spreading: The Pathological Study in Autopsy Cases Using a New Proposed Histological Classification of Gastric Carcinoma N, Goseki 1 1The First Department of Surgery, Tokyo Medical and Dental University, School of Medicine pp.643-649
Published Date 1983/6/25
DOI https://doi.org/10.11477/mf.1403109465
  • Abstract
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 By combining two of the various morphological characteristics of the carcinomatous tissue of stomach, namely, the degree of differentiation of the glandular tubules and the amount of mucus in the cytoplasm, the histological type of the gastric carcinoma was categorized into four groups. “Group Ⅰ: Tubular differentiation―well; mucus in cytoplasm―poor; Group Ⅱ: Tubular differentiation―well; mucus in cytoplasm―rich; Group Ⅲ: Tubular differentiation―poor; mucus in cytoplasm―poor; Group Ⅳ: Tubular differentiation―poor; mucus in cytoplasm―rich.” Then a study about the relation between the histological types of the primary lesions and the modes of development and recurrences of gastric carcinoma in autopsy cases was carried out.

 (1) In Group Ⅰ, the frequency and extent of hematogenous metastasis such as to liver was higher, while (2) in Group Ⅳ, that of lymph node metastasis, direct invasion into surrounding organs, and peritoneal dissemination were higher. (3) In Group Ⅲ, which showed the intermediate mode of development in nature to those of Group Ⅰ and Ⅳ, the frequency and severity of the bone marrow metastasis was the highest. Statistically, the clear significant differences were established in the modes of development and the extent of infiltration among all of the groups.

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