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Localized Primary Amyloidosis of the Stomach, Report of a Case Toshiyuki Kato 1 , Yukifumi Saito 1 , Masayuki Niwa 1 , Kazuei Ogoshi 1 , Hiroshi Tsunoda 3 1Division of Internal Medicine, Cancer Center Niigata Hospital 2Division of Puthology, Cancer Center Niigata Hospital pp.211-216
Published Date 1988/2/25
DOI https://doi.org/10.11477/mf.1403107914
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 A 51-year-old woman was found to have abnormality in the gastric antrum by mass screening and diagnosed as having erosive gastritis endoscopically in Dec. 1979. Follow-up study of upper GI series performed in April 1987 showed polypoid lesions and thickened mucosa suggesting scirrhous type carcinoma. Subsequently performed endoscopic examination revealed thickened elastic mucosa with slight discoloration, irregularly elevated mocosa and multiple erosion. Biopsy specimens showed amyloid in the gastric submucosa. Biopsies of other places of the GI tract, however, were all negative for amyloid deposition.

 Total gastrectomy was performed in July 1987 because of mucosal friability and progressive lesions. In the resected stomach, amyloid (light chain protein λ) was observed in the antrum and the lower portion of the body. Amyloid was also found in the regional lymph nodes along the lesser curvature of the stomach. Liver biopsy performed during operation was negative for amyloid.

 Based on these findings, this case was diagnosed as localized primary amyloidosis of the stomach.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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