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Recent Development in Histopathology of Submucosal Tumor of the Stomach: Especially Immunohistochemical Diagnosis Teruyuki Hirota 1 , Ikuro Koba 1 , Hiroyuki Oono 1 , Masayuki Itabashi 1 , Yuko Yamauchi 1 1Pathology Division, National Cancer Center Research Institute pp.1019-1029
Published Date 1989/9/25
DOI https://doi.org/10.11477/mf.1403106561
  • Abstract
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 Submucosal tumors mainly consist of non-epithelial tumors most of which are spindle-cell tumor and are difficult in differential diagnosis each other. Recent advances in immunohistochemistry made it possible to identify and demonstrate the presence of various material in tumor cells such as filaments of cytoskeleton and products of cells.

 The immunohistochemical staining based on antigen antibody reaction in which a certain enzyme (usually peroxidase) bounded to antibody will play a roll in producing a color through its biochemical reaction with substrate. There are two popular immunohistochemical procedures: one of them is peroxidase-antiperoxidase complex (PAP) method, and the other is avitin-biotin complex (ABC) method. The latter contains lection (avitin-biotin) reaction in the procedures and is said to be more sensitive than PAP method.

 The antibodies commonly used for differential diagnosis of submucosal tumor in the stomach are those for vimentin, desmine, myosin, S-100 protein, neuronspecific enolase and so on.

 In the present paper, we described clinicopathological and immunohistochemical findings of various submucosal tumors in the stomach.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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