Clinicopathological Study of the Gastrointestinal Lesions of Japanese AIDS Patients Toru Igari 1 1Department of Pathology, Tokyo Metropolitan Komagome Hospital Keyword: AIDS , 消化管病変 pp.963-970
Published Date 1997/6/25
DOI https://doi.org/10.11477/mf.1403105170
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 I studied gastrointestinal lesions in 51 autopsy cases of acquired immunodeficiency syndrome from a clinicopathological viewpoint. Cytomegalovirus infection existed in 17 cases as esophageal ulcers, gastric erosion & ulcers, enterocolitis & ulcers. Microscopically, cytomegalic inclusions were found within not only the epithelium and endothelium but also within the intermuscular plexus and proper muscle cells presenting as necrosis. Mycobacterium avium-intracellulare had infected intestines in four cases and was always accompanied with dissemination. Acid-fast bacilli were isolated from stools in three cases. Macroscopically, the infected enteric mucosa showed thick and finely granular patterns or scattered tuberculous patterns. Candidiasis was the most commonly found complication in the course of AIDS and caused oroesophagitis, but in many cases it was reduced or cured at autopsy. Cryptosporidiosis was detected in one case, presenting as severe watery diarrhea. Kaposi's sarcomas ordinarily formed skin or oral lesions and accompanied gastrointestinal lesions in eight cases. Their intestinal manifestations were usualy mild but sometimes they caused severe bleeding as shown in one case.

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