Gardner's Syndrome Initially Suggested by Gastroduodenal Adenomas and Adenocarcinoma of the Duodenal Papilla, Report of a Case Noriko Egami 1 , Shuji Tada 1 , Kazuhiko Hirota 1 1Department of Gastroenterology, Saiseikai Kumamoto Hospital Keyword: Gardner症候群 , 家族性大腸腺腫症 , 胃腺腫 , 十二指腸腺腫 , 十二指腸乳頭部癌 pp.623-629
Published Date 1997/3/25
DOI https://doi.org/10.11477/mf.1403105108
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 A 45-year-old man was admitted to our hospital because gastric radiography at a medical ckeckup disclosed abnormal findings. Upper gastrointestinal endoscopy and biopsies showed multiple tubular adenomas in the antrum and duodenum, and a well differentiated adenocarcinoma at the major papilla of the duodenum. Further examinations revealed adenomatosis of the colorectum, osteoma, and the epidermoid cyst of the breast. Therefore, he was diagnosed as having Gardner's syndrome. Because radiographic and endoscopic ultrasonographic findings showed that the carcinoma at the papilla was localized within the mucosal layer, open surgical polypectomy of the tumor was performed. The tumor was intramucosal papillary adenocarcinoma measuring 3.0×2.3 cm in size. Recent reports reveal that multiple neoplastic lesions do exist in the upper gastrointestinal tract in patients with FAP. Thus, careful examinations by upper gastrointestinal endoscopy and radiography should be undertaken to detect the neoplastic lesions while they are in the early stage of growth.

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