Japanese

A Correlation of Intramural Tumor Invasion with Mucin Histochemistry, and Immunohistochemical Expressions of Oncogene-related Proteins in Early Gastric Carcinomas Masafumi Oya 1 , Takashi Yao 1 , Masazumi Tsuneyoshi 1 1The Second Department of Pathology, Faculty of Medicine, Kyushu University Keyword: 壁深達度 , 粘液組織化学 , 免疫組織化学 , p53 , c-erbB-2 pp.31-39
Published Date 1997/1/25
DOI https://doi.org/10.11477/mf.1403104948
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 We categorized gastric carcinomas invading the submucosa as tumors restricted to the superficial submucosa (sm1), tumors invading the deep portion of the submucosa (sm3), and others (sm2), along with lymph node involvement (NI).

 The frequency of NI was 8.1%, 17.0% and 30.4% among the cases with sm1, sm2 and sm3, respectively, which percentage increased with an intramural tumor invasion and was significantly higher than that (2.2%) of intramucosal carcinoma cases.

 Areas of both mucosal and submucosal lesions and the ratio of sm to m in tumoral areas in cases with NI were significantly larger than those in cases without NI. Lymphatic permeation was more frequently observed in cases with NI than in cases without NI.

 In mucin histochemistry, gastric-type mucin was frequently observed even in intramucosal carcinoma cases with NI, whereas the mucin was gradually expressed in non-metastasizing carcinoma cases as intramural tumor invasion. It was suggested that expressed mucin may be related with biological aggressiveness of the tumor. Overexpression of p53 and c-erbB-2 proteins were not correlated with NI.

 All six cases of sm1 with NI showed macroscopically depressed lesions with ulcers or ulcer scars and poorly-differentiated adenocarcinomatous components. Lymphatic permeation was also detected in four (67%) of the cases.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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