Enlarged Fold Gastritis Improved by Eradication of Helicobacter pylori, Report of a Case Katsuhiko Higuchi 1 , Satoshi Tanabe 1 , Junko Ichikawa 1 , Tohru Sasaki 1 , Masahito Oida 2 1Department of Gastroenterology, Kitasato University East Hospital 2The Health Care Center, Sagamino Social Insurance Hospital Keyword: 胃巨大皺襞症 , Helicobacter pylori , 除菌療法 pp.1741-1746
Published Date 2002/12/25
DOI https://doi.org/10.11477/mf.1403104616
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 A Randwall-like appearance with barium-poolings on the lesser curvature of the corpus was detected in a 72-year-old man during a barium meal examination. Laboratory tests revealed normal proteinemia. Gastroendoscopy revealed enlarged folds without erosion and an ulcerative lesion on the lesser curvature of the corpus. Endoscopic ultrasonography revealed a remarkably thickened mucosal layer. To make an accurate diagnosis histologically, endoscopic mucosal resection for an enlarged gastric fold was performed. Histological findings showed corkscrew-like hyperplasia in the surface epithelium and mucosal infiltration by inflammatory cells. He was then diagnosed as having enlargedfold gastritis. Since Helicobacter pylori infection was detected, eradication therapy was performed (lansoplazole 60 mg, amoxicillin 1,500 mg and clarithromycin 400 mg for 7 days) . As a result, Helicobacter pylori was eradicated. After this treatment, the enlarged gastric folds and histological findings of the gastric mucosa were normalized.

 This case suggests Helicobacter pylori infection plays some etiological role in enlarged fold gastritis. This was shown by the improvement of the disease by eradication of Helicobacter pylori.

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