Clinicopathological Changes of Gastric MALT Lymphomas with or without Eradication of Helicobacter pylori Hiroyuki Ono 1 1Department of Internal Medicine, National Cancer Center Hospital Keyword: MALTリンパ腫 , Helicobacter pylori , 遺伝子診断 pp.83-92
Published Date 1996/1/25
DOI https://doi.org/10.11477/mf.1403103916
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 We followed natural couses of eight cases of low-grade MALT lymphomas and four of atypical lymphoid cell proliferation (AL). The mean observation period was three years, raising from two months to 7.5 years. Although four cases of low-grade MALT lymphomas had no ovbious histological changes in biopsy specimens, remained four cases and all of AL cases changed to chronic gastritis histologically.

 Then, nine cases of low-grade MALT lymphomas and one case of AL underwent eradication of Helicobacter pylori (H. pylori). Histological findings changed to chronic gastritis in five cases with MALT lymphoma and one case with AL, four of which accompanied with improved endoscopic findings. In only one patient with MALT lymphoma endoscopic findings became worse. Two cases which showed monoclonal pattern of IgH rearrangement by PCR changed to polyclonal pattern after eradication of H. pylori. No LOH of APC, DCC, p53 genes and no bcl-2 rearrangement were detected in all cases before and after eradication.

 We concluded that pathological and endoscopic findings of MALT lymphomas were changeable during a long observation period. Furthermore, eradication of H. pylori would be valuable approach for precise diagnosis of lymphoproliferative disorders of the stomach. Gene analysis of IgH might be useful for differential diagnosis from MALT lymphoma and borderline lesion.

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