Co-expression of Vimentin and Cytokeratins in Gastric Carcinoma, Report of a Case Masakazu Hattori 1 , Yasuharu Kaizaki 2 , Osamu Hosokawa 1 1Department of Surgery, Fukui Prefectural Hospital 2Department of Pathology, Fukui Prefectural Hospital Keyword: 5型胃癌 , 胃低分化型腺癌 , vimentin陽性胃癌 pp.1321-1326
Published Date 2001/9/25
DOI https://doi.org/10.11477/mf.1403103331
  • Abstract
  • Look Inside

 A 32-year-old female was admitted to our hospital for further examination of epigastralgia. X-ray and endo-scopic examination showed a large fungating-type tumor in the greater curvature of the upper third of the stomach. As biopsy revealed that it was a poorly differentiated adenocarcinoma, an operation was performed under the diagnosis of advanced gastric cancer.

 Histopathological examination of the resected tumor, measuring 11.8×11.6 cm, showed that the tumor cells were polygonal in shape with scanty cytoplasm and the nuclei were pleomorphic.

 Immunohistochemically, tumor cells were diffusely positive for vimentin and cytokeratin. The lesion was finally diagnosed as poorly differentiated gastric carcinoma with co-expression of vimentin and cytokeratins. The patient developed multiple metastasis in many organs and died 10 months postoperatively.

Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院