Acute Adult T-cell Leukemia (ATL) with Various Formed Minute Ulcers, Diagnosed in a Gastrointestinal Radiography, Report of a Case Yousuke Kikuchi 1 , Kuniaki Takenaka 1 , Toshihiro Sakurai 1 , Akinori Iwashita 2 1Department of Gastroenterology, Fukuoka University Chikushi Hospital 2Department of Pathology, Fukuoka University Chikushi Hospital Keyword: ATL , 消化管病変 pp.889-894
Published Date 1999/6/25
DOI https://doi.org/10.11477/mf.1403103085
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 A 58-year-old man was admitted to our hospital for further evaluation of fever of unknown origin. Small intestinal radiography revealed multiple small nodules with central depression in the upper jejunum. Double contrast small intestinal radiography was carried out continuously and multiple minute ulcers according to Peyer's patch were revealed. Total colonoscopy revealed aphtoid ulcers and invasive atypical lymphoid cells were found in the biopsy specimens. Morphologically atypical lymphocytes were found in peripheral blood and anti HTLV-1 antibody was positive. Using proviral DNA, the patient was diagnosed as having adult T-cell leukemia (ATL) and the intestinal findings were considered to be invasive lesions. The submucosal tumor-like small nodules were remarkably similar to those reported in a previous case report of the gastrointestinal lesion of ATL. Moreover, this is the first report of a patient with ATL which was diagnosed using the double contrast method of small intestinal radiography. Therefore, these findings should be reported for the light they sled on the mechanism of invasion in the patients with ATL.

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