Endoscopic Findings of Dysplastic Epithelium of the Esophagus Minoru Muraoka 1 , Teruo Kouzu 1 1The Second Department of Surgery, Chiba University School of Medicine Keyword: 食道dysplasia , ルゴール染色 , 細胞核DNA量 pp.163-173
Published Date 1991/2/25
DOI https://doi.org/10.11477/mf.1403102456
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 We studied on classification of the esophageal dysplastic epithelium by lugol method of endoscopy. We divided the lugol-unstained lesions into three grades (grade Ⅲ-Ⅴ).Grade Ⅲ lesions seemed to correspond to benign lesions and grade Ⅳ lesions dysplastic epithelial lesions. Most of the squamous carcinoma were found in grade V lesions. The degree of lugolunstainedness of the esophageal epithelium corresponded to the glycogen contents in the epithelium. We also studied on the DNA contents of lugol-unstained lesions using a fluorescent microscope. As to the analysis of histogram of DNA pattern, the incidence of aneuploidy pattern increased in proportion to the degree of dysplasia. As to the DNA value and the range of it, those of dysplasia are between those of normal epithelium and squamous cell carcinoma, and they also increased with the degree of dysplasia. In the near future, it is expected that the analysis of esophageal dysplasia leads us to estimate its prognosis.

Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.


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