治療面からみた腸管Behçet病・単純性潰瘍の経過

Treatment for Intestinal Behçet's Disease and the So-called ‘Simple Ulcer' by Oral and Local Spraying of Mesalazine

要旨　腸管Behçet病（BD）・単純性潰瘍（SU）の潰瘍に対して，経内視鏡的にメサラジン注腸液を10例に撒布した．深掘れで大きな典型的な潰瘍に対してはメサラジンの撒布を行わなかった．潰瘍の多くはメサラジン撒布により縮小した．しかし，潰瘍は再発することが多いため，経過をみて潰瘍が再発した場合にはメサラジン撒布を行った．メサラジンによる経口投与と局所的撒布によって，73％に潰瘍の縮小または潰瘍の深さが浅くなることを認めた．腸管の潰瘍は再発するので，定期的に内視鏡検査を行う必要がある．治療効果SUとBDの潰瘍に対してメサラジンの経口投与とともに，メサラジン注腸液を経内視鏡的に潰瘍に対して撒布することは試みる価値のある治療法と考える．

　Recently we have encounterd 10 cases of intestinal Behçet's disease and so-called simple ulcer in patients with complaints of positive fecal occult reaction. Ulcers in the ileocecal area with rectal bleeding were smaller than those associated with abdominal pain. We had been treating 10 cases 〔intestinal Behçet's disease（2 cases）and so-called simple ulcer（8 cases）〕. Ulcers in the ileocaecal area were treated by oral mesalazine（3g/day）and local spraying of mesalazine enema under endoscopy. We have interpreted the results as effective treatment because of decreased size and shallower depth of the ulcer than before examination. We have interpreted results as non-effective because of increased size and greater depth of the ulcer than before the examination. The mesalazine treatment was effective in 73％（19/26）ulcer cases. For patients with ulcers, oral mesalazine and measalazine enema spraying under endoscopy were effective.