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要旨 ESDで切除された早期の分化型胃癌313病変を対象に,低異型度分化型胃癌の内視鏡所見と内視鏡的範囲診断について検討した.低異型度分化型胃癌の内視鏡的特徴として(1)正色調から褪色調を呈し,(2)丈の低い隆起や陥凹を有し,(3)腫瘍径20mm以下が多く,(4)潰瘍所見がなく,(5)area構造を保存し,(6)色素撒布後観察でも境界不明瞭となりやすいことが挙げられた.高異型度分化型胃癌に比べ,ESDによる治癒切除率は有意に高いが,側方断端陰性切除に際して重要な範囲診断に関しては,色素観察において2/3周までは境界診断が可能であるものの,多くの病変は一部に不明瞭な部分を有していることに留意し,同部位の詳細な観察が重要と考えられた.
To clarify endoscopic and histopathological features of low grade gastric differentiated adenocarcinoma, 313 early gastric cancers(EGC)were divided into 116 low grade cancers(LGC)and 197 high grade cancers(HGC)according to their histological features. Firstly, we investigated the endoscopic features of LGC in comparison with HGC. Secondly, we evaluated the predictive factor of endoscopically obscure margin with chromoendoscopy. Significant endoscopic and pathologic features of LGC were,“isochromatic and pale",“less than 20mm in diameter",“without concomitant ulcer",“mucosal lobulated pattern preserved" and “obscure margin in chromoendoscopy". In pre-assessment of ESD for LGC, the lateral margin of the lesion could be demarcated clearly in three quarters of the circumferences, however there was usually a small portion with obscure margin. We conclude that a full examination into that partial obscure margin is important for achieving a curative resection of LGC by endoscopic submucosal dissection.
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