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Chracteristic Clinical Findings and Pathological Findings in the Small Intestinal Lesions of the Satoyoshi Syndrome Takashi Nagahama 1 , Toshiyuki Matsui 1 , Akinori Iwashita 2 1Department of Gastroenterology, Chikushi Hospital, Fukuoka University, Chikusino, Japan 2Department of Pathology, Chikushi Hospital, Fukuoka University, Chikusino, Japan Keyword: 里吉病 , 全身こむら返り病 , 小腸病変 , gastroenterocolitis cystica polyposa , 吸収不良症候群 pp.713-718
Published Date 2008/4/24
DOI https://doi.org/10.11477/mf.1403101354
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 Satoyoshi is a disease of unknown etiology characterized by three principal manifestations: progressive muscle spasms (cramps), generalized alopecia, and diarrhea. In rare cases in which the diarrhea is severe organic abnormalities are observed throughout the entire digestive tract, and they give rise to a malabsorption syndrome, but few cases have been accumulated, and many aspects of the pathology remain unknown. The characteristic clinical findings and histopathological findings in the small intestine lesions in the cases that have been reported, including our own, can be summarized as follows. The radiographic findings show loss of Kerckring's folds in the small intestine, and the mucosal surface consists of densely arrayed fine granular protrusions of various size or irregularly shaped nodular protrusions, but no clear erosions or ulcers are seen. It has a pumiceous appearance. Endoscopically, the mucosal surface has a mottled red appearance, and fine granular mucosal change with scattered white patches, or polypoid protrusions formed by clusters of enlarged villi are seen. The histopathological findings at autopsy in the cases that have exhibited severe digestive system manifestations have shown a picture of gastroenterocolitis cystica polyposa (GCP) throughout the digestive tract except in the esophagus.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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