Vimentin-positive Esophageal Undifferentiated Carcinoma of the Non-small-cell Type Arising in Barrett's Esophagus, Report of a Case Atsuhiko Murata 1 , Kazuya Akahoshi 1 , Yumiko Kumashiro 2 , Takashi Yao 2 , Mitsuhide Kimura 1 , Noriaki Matsui 1 , Yasuaki Motomura 1 , Masaru Kubokawa 1 , Jiro Ouchi 1 , Kuniomi Honda 1 , Shingo Endo 1 , Masayuki Watanabe 3 , Masahumi Oya 4 , Kazuhiko Nakamura 5 , Syuichiro Nishihara 6 1Department of Gastroenterology, Aso Iizuka Hospital, Iizuka, Japan 2Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyusyu University, Fukuoka, Japan 3Department of Surgery, Aso Iizuka Hospital, Iizuka, Japan 4Department of Pathology, Aso Iizuka Hospital, Iizuka, Japan 5Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 6Nishihara Internal Medicine and Gastroenterological Clinic, Iizuka, Japan Keyword: 非小細胞型未分化癌 , vimentin , Barrett食道 pp.1543-1549
Published Date 2007/9/25
DOI https://doi.org/10.11477/mf.1403101202
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 A 65-year-old man with anemia and dysphagia was referred to our hospital with a diagnosis of esophageal tumor of the lower esophagus.

 X-ray examination revealed an ulcerative lesion with coarse nodules in the surface, approximately 6 cm in length in the lower esophagus. Esophagogastroduodenoscopy showed an irregular ulcerative lesion with a smooth-surfaced small peripheral upheaval, and the tumor was surrounded by smooth-surfaced erythematous mucosa. The biopsy specimen taken from the tumor was diagnosed as undifferentiated carcinoma, and that from the erythematous mucosa revealed Barrett's epithelium, respectively. EUS revealed a hypoechonic mass expanding into the adventitia(Ad)with lymph node involvement(N2). Preoperative CT examination revealed no distant metastasis. The lesion was preoperatively diagnosed as stage III undifferentiated carcinoma arising in Barrett's esophagus, and the patient underwent surgical resection.

 Histologically, the tumor was positive for vimentin and diagnosed as a primary esophageal undifferentiated carcinoma of the non-small-cell type arising in Barrett's esophagus. The tumor size was 57×29 mm, pT2(mp), ly3, v1, infα, n4. After surgical resection, he was treated with chemotherapy using S-1(100 mg/day). However, he died due to aspiration pneumonia 10 months later. This is a very rare case of vimentin-positive esophageal undifferentiated carcinoma of the non-small-cell type arising in Barrett's esophagus.

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