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Hydrocephalus and Dementia Masakazu MIYAJIMA 1 , Yuriko KAWAI 1 , Hideki BANDAI 1 1Department of Neurosurgery, Juntendo Tokyo Koto Geriatric Medical Center Keyword: ハキム病 , 特発性正常圧水頭症 , 認知症 , Hakim's disease , idiopathic normal pressure hydrocephalus , dementia pp.969-974
Published Date 2025/9/10
DOI https://doi.org/10.11477/mf.030126030530050969
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 Idiopathic normal pressure hydrocephalus (iNPH), also known as Hakim's disease, is a major cause of reversible dementia in adults. iNPH primarily affects frontal lobe-related cognitive functions, including attention, executive function, and working memory, even in early stages. Although memory impairment is also present, recognition memory is often preserved, distinguishing iNPH from Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD), especially apathy, depression, and anxiety, are common in iNPH and are generally less active than those seen in AD. Neuropsychological assessments reveal significant impairments in frontal lobe tests such as the Frontal Assessment Battery and Trail Making Test-B. Shunt surgery leads to substantial improvement in attention and executive function, reflecting the reversible nature of iNPH. However, memory functions, particularly delayed recall, show limited recovery, indicating possible overlap with neurodegenerative mechanisms. Early surgical intervention is associated with better outcomes, while delayed treatment or advanced brain atrophy may reduce effectiveness. Comprehensive cognitive evaluation is essential for assessing treatment response, planning rehabilitation, and providing appropriate patient and family guidance.


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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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