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Preoperative Analysis of Platelet Aggregability in Carotid Surgery Yoichi MOROFUJI 1 , Gohei SO 1 , Takeshi HIU 1 , Junichi KAWAKUBO 1 , Kentaro HAYASHI 1 , Naoki KITAGAWA 1 , Minoru MORIKAWA 2 , Kazuhiko SUYAMA 1 , Izumi NAGATA 1 1Department of Neurosurgery,Nagasaki University School of Medicine 2Department of Radiology,Nagasaki University School of Medicine Keyword: platelet aggregation , carotid endarterectomy , carotid artery stenting , antiplatelet therapy , whole blood aggregometry pp.459-463
Published Date 2011/5/10
DOI https://doi.org/10.11477/mf.1436101425

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  • Abstract
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 To evaluate the relationship between preoperative analysis of platelet aggregability and perioperative complications,we analyzed 42 patients who underwent carotid endarterectomy or carotid artery stenting. The effect of antiplatelet drugs was tested by whole blood aggregometry. ADP (adenosine-diphosphoric acid) and collagen were used as agonists. According to platelet aggregability,patients were classified into 4 groups (class A: highly inhibited,class B: moderately inhibited,class C: normally inhibited,class D: non-inhibited). Seven (32%) of 22 patients were stratified as clopidogrel nonresponders,whereas four (10%) of 40 patients were aspirin nonresponders. Hemorrhagic complications were registered in four patients. All of them were classified as class A. Ischemic complications occured in two patients,one was classified as class C,the other was class D. Preoperative analysis of platelet aggregability could be useful to reduce the risk of perioperative complications after carotid surgery.


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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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