Effects of Metabolic Inhibitors and Ouabain on Transport of Ions through Frog Skin

　It might reasonably be expected that various metabolic inhibitors inhibit active transport of matter, a process which requires energy derived from cellular metabolism．However, Schatzmann^13） showed several years ago that certain cardiac glycosides and aglycones inhibited selectively the active transport of Na and K in human red cells．Since then these drugs have been studied considerably with respect to the inhibitory action on active transport in several living membranes．

　Since the work of Ussing and Zerahn^15）, the active Na transport across the frog skin has been studied extensively because with this material it is relatively easy to obtain various information about the active transport of ions.