CIDPの歴史—疾患概念の確立，治療法の変遷と未来

History of Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Establishment of Disease Concepts, Changes, and the Future of Treatment

2025年は，Peter J Dyck博士がchronic inflammatory polyradiculoneuropathy（CIP）という病名を初めて用いた論文を上梓して50年という節目の年にあたる。それまで雑多な名称で呼ばれていたCIDPが1つの疾患概念としてまとめ上げられたことにより，その診断と治療は大きな前進を遂げた。この論文では，疾患概念の確立と日本での受容，治療法の変遷の概要と現況をまず述べる。しかし，CIDPの治療はまだまだすべての患者に満足な結果をもたらすところまでは発展していない。本論文の後半では，考えられる病態メカニズムに立脚した近未来の治療展望を論じる。

Abstract

The year 2025 marks the 50th anniversary of the publication of the first paper by Dr. P.J. Dyck that uses the disease name “chronic inflammatory polyradiculoneuropathy (CIP)”. By combining chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), which was previously termed using miscellaneous names, into a single disease concept, a major step forward was made in its diagnosis and treatment. In this paper, we first address the establishment of the disease concept, its acceptance in Japan, and the transition and current status of treatment methods. However, CIDP treatment has not yet been developed to provide satisfactory results for all patients. In the second half of this paper, we discuss therapeutic prospects of the near future based on possible pathological mechanisms.