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Platelet Microtubules and Giant Granules in the Chediak-Higashi Syndrome James G. White pp.837-839
Published Date 1978/10/1
DOI https://doi.org/10.11477/mf.1543201719
  • Abstract
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Platelets from a child with the characteristic clinical and laboratory features of the Chediak-Higashi Syndrome (CHS) were evaluated in the electron microscope. Rare peripheral blood platelets were found to contain the giant abnormal granules observed previously in nearly all leukocytes. The discoid CHS platelets contained circumferential bundles of microtubules identical to those present in normal cells. CHS platelet microtubules responded in the same manner as those in normal cells when patient platelets were exposed to collagen, cold, or to chilling and rewarming. The findings are inconsistent with the concept that a defect in microtubule assembly is the fundamental abnormality responsible for aberrant function of CHS cells.


Copyright © 1978, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1375 印刷版ISSN 0301-2611 医学書院

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