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Giant Cell Tumor Originating in the Sphenoid Bone : a case report Yukinari KAKIZAWA 1 , Yuichirou TANAKA 1 , Hisayoshi TAKASAWA 1 , Fusakazu OYA 1 , Tsuyoshi TADA 1 , Kazuhiko KYOSHIMA 1 , Shigeaki KOBAYASHI 1 1Department of Neurosurgery, Shinshu University School of Medicine Keyword: giant cell tumor , sphenoid bone , transsphenoidal surgery , irradiation , chemotherapy pp.667-672
Published Date 1999/7/10
DOI https://doi.org/10.11477/mf.1436901754
  • Abstract
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The authors report a case of giant cell tumor originating in the sphenoid bone. A 29-year-old womanpresented with headache and diplopia. Bilateral ophthalmoplegia developed and MRI showed rapid growthof the tumor in spite of transnasal removal and conventional radiation therapy. The second transnasalsurgery was performed 3 weeks after completion of radiotherapy. The symptoms were relieved except forright abducens palsy. Chemotherapy with cisplatin and etoposide was started after the second operation.The patient regained full ocular movement several months after the operation. Clinical remission has con-tinued for four years. We conclude that the combination of repeated operations in the initial phase of rapidtumor growth, irradiation and chemotherapy is important to achieve tumor control.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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