雑誌文献を検索します。書籍を検索する際には「書籍検索」を選択してください。

検索

書誌情報 詳細検索 by 医中誌

Japanese

SOD1 transgenic mice Noriyuki SHIBATA 1 , Makio KOBAYASHI 1 , Asao HIRANO 2 1Department of Pathology, Tokyo Women's Medical University 2Division of Neuropathology, Montefiore Medical Center Keyword: スーパーオキシド・ジスムターゼ , トランスジェニックマウス , 筋萎縮性側索硬化症 , 酸化的ストレス , 蛋白翻訳後修飾 pp.294-305
Published Date 1999/4/10
DOI https://doi.org/10.11477/mf.1431901049
  • Abstract
  • Look Inside

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that primarily involves the motor neuron system. Recent studies have obtained evidence that mutations in the gene for superoxide dismutase-1 (SOD1) are associated with 20% of patients with familial ALS. Although neither wild-type SOD1-overexpressing mice nor SOD1-knockout mice show ALS-like disorder, transgenic mice expressing SOD1 mutants (G93A, G37R, G86R, G85R and D90A) detected in familial ALS cases develop a motor neuron disease with a variety of clinicopathological features corresponding to mutation sites and expression levels of a mutated gene.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

関連文献

もっと見る

文献を共有