BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 11 (November 2018)

Delusional Misidentification Syndromes in Organic Brain Disorders Yoshinari Kawai 1 1Department of Neurology, Oyamada Memorial Spa Hospital Keyword: 妄想性誤認症候群 , カプグラ症候群 , フレゴリ症候群 , 重複記憶錯誤 , 幻の同居人 , delusional misidentification syndrome , Capgras syndrome , Frégoli syndrome , reduplicative paramnesia , phantom boarder pp.1181-1191
Published Date 2018/11/1
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Delusional misidentification syndromes (DMSs) are a fascinating group of disorders involving a fixed, false belief about the identity of persons, places, and objects in one's environment. DMSs include Capgras syndrome, Frégoli syndrome, intermetamorphosis, the syndrome of subjective doubles, and reduplicative paramnesia. Although DMSs have been described in patients with focal neurological lesions, they are more commonly associated with neurodegenerative diseases, specifically dementia with Lewy bodies. Lesion network mapping was used to identify brain regions functionally connected to the lesion locations in patients with lesion-induced DMSs. The left retrosplenial cortex and the right ventral frontal cortex/anterior insula were functionally connected to almost all lesion locations. In a model of Capgras symptom as a mirror of prosopagnosia, there are two routes of visual recognition; one covert and one overt. Capgras symptom represents an interruption to the covert route with an intact overt route. This model, however, does not explain other DMSs. Therefore, propose a new model where the delusional belief content in DMSs results from dysfunctional linking between externally perceived objects and appropriately retrieved internal autobiographical memories associated with an object.

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BRAIN and NERVE-神経研究の進歩
70巻11号 (2018年11月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院