Diagnosis and Novel Treatment Approaches in Restless Legs Syndrome: II. Treatment Koichi Hirata 1 , Keisuke Suzuki 1 1Department of Neurology, Dokkyo Medical University Keyword: restless legs syndrome , periodic limb movement in sleep , dopamine agonist , alpha-2-delta ligand pp.1391-1399
Published Date 2013/11/1
DOI https://doi.org/10.11477/mf.1416101651
  • Abstract
  • Look Inside
  • Reference


 The symptoms of restless legs syndrome (RLS) can be managed effectively by treatment. The pathophysiology of primary RLS is only partly understood; however, a strong association with brain iron deficiency, which possibly impairs dopaminergic function, has been identified.

 Dopamine agonists are the mainstay of RLS treatment, but other therapies, including gabapentin, benzodiazepines, and low-potency opioids, are also commonly employed. Recent evidence-based guidelines recommend dopamine agonists or alpha-2-delta ligands as the first-line treatment for RLS depending on patients' clinical background, comorbidity, and severity of the symptoms. In this review, we focus on the pathophysiology, comorbidity, differential diagnosis, and novel treatment approaches of RLS.

Copyright © 2013, Igaku-Shoin Ltd. All rights reserved.


電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院